Antimicrobial Peptide AP00054

     
 

APD ID:

AP00054

 
 

Name/Class:

Bombinin-like peptide 7 (BLP-7, UCLL1; toad, amphibians, animals)

 
 

Source:

Oriental fire-bellied toad/frog, Bombina orientalis, Asia

 
 

Sequence:

GIGGALLSAGKSALKGLAKGLAEHFAN

 
 

Length:

27

 
 

Net charge:

3

 
 

Hydrophobic residue%:

48%

 
 

Boman Index:

-0.27 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: Q9DET7  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, Anticancer

 
 

Additional info:

A peptide rich in glycines, alanines, and leucines. Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M. luteus, and S. cerevisae Ke T et al., 2012. ALso has anticancer effects on human hepatic adenocarcinoma SK-HEP-1 cells (IC50 0.99 uM), Hep G2 cells (IC50 2.8 uM) and Huh7 cells (IC50 3.8 uM) after 48 h treatment, also human prostate cancer PC3 cells, human lung cancer A549 cells and human melanoma A375 cells at the investigated concentrations (Zhou et al., 2017). Updated 9/2017.

 
       
 

Title:

Sequence of a gene from Bombina orientalis coding for the antimicrobial peptide BLP-7.

 
 

Author:

Miele R, Borro M, Fiocco D, Barra D, Simmaco M.2000

 
 

Reference:

Peptides 2000; 21:1681-1686. PubMed.

 
       

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