Antimicrobial Peptide AP00052

     
 

APD ID:

AP00052

 
 

Name/Class:

Bombinin-like peptide 3 (XXA, BLP-3, XXA, UCLL1c; toad, amphibians, animals)

 
 

Source:

Oriental fire-bellied toad/frog, Bombina orientalis, Asia

 
 

Sequence:

GIGAAILSAGKSALKGLAKGLAEHF

 
 

Length:

25

 
 

Net charge:

3

 
 

Hydrophobic residue%:

52%

 
 

Boman Index:

-0.52 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

SwissProt ID: P29004  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal,

 
 

Additional info:

Active against N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica, and N. cinerea (59-100% at 20 ug/ml). Also active against B. megaterium BmII, S. aureus Cowan1, E. coli D21, E. coli D22, Y. pseudotubercolosis, P. aeruginosa ATCC 15692, and C. albicans (Simmaco et al. 1998). Helical in 40% TFE. Updated Jan2017; 5/2020.

 
       
 

Title:

Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.

 
 

Author:

Gibson BW, Tang D, Mandrell R, Kelly M, Spindel ER.1991.

 
 

Reference:

J. Biol. Chem. 1991; 266: 23103-23111. PubMed.

 
       

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