Antimicrobial Peptide AP00029

     
 

APD ID:

AP00029

 
 

Name/Class:

Cecropin A(1-8)-Magainin 2(4-12) hybrid (CE-MA) (CAMEL; synthetic, BBL)

 
 

Source:

peptide hybrid

 
 

Sequence:

KWKLFKKIKFLHSAKKF

 
 

Length:

17

 
 

Net charge:

8

 
 

Hydrophobic residue%:

47%

 
 

Boman Index:

1.12 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1F0F   Go to PDB

 
 

Activity:

antiviral, antiparasitic, Antimalarial, Cancer cells

 
 

Additional info:

Alpha helix 5 to 13 in DPC micelles. You can rotate, zoom, and view the 3D structure here in the PDB . CAMEL (seq: KWKLFKKIGAVLKVL) is also a hybrid peptide obtained by combining residues 1-7 of cecropin (CA) and residues 2-9 of melittin (M). D-form tends to more active and more stable than the L-form (D>L). Transgenic plants: expression of this peptide in tobacco or potato led to disease-resistant plants against bacteria and fungi (ref). Another hybrid CA(1-8)M(1-18) is active against P. falciparum.

 
       
 

Title:

Activities of synthetic hybrid peptides against anaerobic bacteria: aspects of methodology and stability

 
 

Author:

Oh H, Hedberg M, Wade D, Edlund C.2000

 
 

Reference:

Antimicrob Agents Chemother. 2000 Jan;44(1):68-72.PubMed.

 
       

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