Antimicrobial Peptide AP00028

     
 

APD ID:

AP00028

 
 

Name/Class:

Tricyclic peptide RP 71955 (a class 1 lasso peptide, 2S=S; lactam; XXJ; UCSB1a; bacteriocins; Gram-positive bacteria, prokaryotes, ZZHb)

 
 

Source:

Streptomyces strains AA3891

 
 

Sequence:

CLGIGSCNDFAGCGYAVVCFW

 
 

Length:

21

 
 

Net charge:

-1

 
 

Hydrophobic residue%:

61%

 
 

Boman Index:

-0.94 kcal/mol

 
 

3D Structure:

beta

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1RPB   Go to PDB

 
 

Activity:

antiviral, anti-HIV,

 
 

Crucial residues:

 
 

Additional info:

An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. In contrast. Class 2 lassos do not have disulfide bonds. You can rotate, zoom, and view the 3D structure here in the PDB .

 
       
 

Title:

Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.

 
 

Author:

Helynck G, Dubertret C, Mayaux JF, Leboul J.1993

 
 

Reference:

J Antibiot (Tokyo). 1993 Nov;46(11):1756-7. PubMed.

 
       

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