Detailed Information About Peptide AP00028

APD ID:

AP00028

Name:

Siamycin II (Tricyclic peptide RP 71955, BMY 29303, XXC) (bacteria, ZZHb)

Source:

Streptomyces strains AA3891

Sequence:

CLGIGSCNDFAGCGYAVVCFW

Length:

21

Structure:

Bridge

Method:

NMR

Additional info:

An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19.

Crucial residues:

Structure was determined by NMR (Biochemistry 1994; 33:42-50).

Activity:

Virus,

Net charge:

-1

Hydrophobic residue%:

61%

Boman Index:

-0.94 kcal/mol

SwissProt ID:

PDB ID: 1RPB   Go to PDB

Reference:

J Antibiot (Tokyo). 1993 Nov;46(11):1756-7

Author:

Helynck G, Dubertret C, Mayaux JF, Leboul J.

Title:

Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.