Antimicrobial Peptide AP00027

     
 

APD ID:

AP00027

 
 

Name/Class:

Combi-1 (Arg-rich; Trp-rich; XXE, XXA, synthetic; Derivative: cyclized hexamer, BBL. SeqAR)

 
 

Source:

Synthetic Combinatorial peptide Library

 
 

Sequence:

RRWWRF

 
 

Length:

21

 
 

Net charge:

-1

 
 

Hydrophobic residue%:

57%

 
 

Boman Index:

6.18 kcal/mol

 
 

3D Structure:

NonHelixBeta

 
 

Method:

NMR

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

anti-Gram+ & Gram-, antifungal,

 
 

Additional info:

N-terminal acetylation and C-terminal amidation. Also active against E. coli ATCC 2592, M. luteus, and S. cerevisae Ke T et al., 2012. 3D structure in SDS or DPC micelles was reported by Jing W, Hunter HN, Hagel J, Vogel HJ in J Pept Res. 2005 May;65(5):491-501 and the authors propose that the main bactericidal site of action of these peptides might be located inside bacteria. Cyclization improves both antimicrobial activity and cell selectivity (Dathe et al 2004 Biochemistry 43: 9140-50).

 
       
 

Title:

The antimicrobial activity of hexapeptide derived from synthetic combinatorial libraries

 
 

Author:

Blondelle SE, Takahashi E, Dinh KT, and Houghten, RA1995

 
 

Reference:

J Appl Bacteriol 1995; 78: 39-46. PubMed.

 
       

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