Antimicrobial Peptide AP00016

     
 

APD ID:

AP00016

 
 

Name/Class:

Aurein 2.3 (XXA, UCLL1c; frog, amphibians, animals)

 
 

Source:

Southern bell frog Litoria aurea or Litoria raniformis, Australia

 
 

Sequence:

GLFDIVKKVVGAIGSL

 
 

Length:

16

 
 

Net charge:

2

 
 

Hydrophobic residue%:

56%

 
 

Boman Index:

-1.01 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P82390  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antifungal, Cancer cells

 
 

Crucial residues:

Gain anticancer activity if change I13 to F (change to P82392)

 
 

Additional info:

Active against L. lactis (MIC 25 ug/ml) (provided by Chunfeng Wang). C-terminal NH2. Solution NMR in 25% TFE established a helical structure (Biophys. J 2007; 92: 2854). Found in multiple species. Updated 9/2017.

 
       
 

Title:

The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

 
 

Author:

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000

 
 

Reference:

Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.

 
       

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