Antimicrobial Peptide AP00013

     
 

APD ID:

AP00013

 
 

Name/Class:

Aurein 1.2 (XXA, UCLL1c; frog, amphibians, animals; BBMm; ZZH)

 
 

Source:

Southern bell frog Litoria aurea and Litoria raniformis, Australia

 
 

Sequence:

GLFDIIKKIAESF

 
 

Length:

13

 
 

Net charge:

1

 
 

Hydrophobic residue%:

53%

 
 

Boman Index:

0.12 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1VM5   Go to PDB

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antifungal, anti-HIV, Cancer cells

 
 

Crucial residues:

F13 and C-terminal amidation

 
 

Additional info:

It showed a good activity against L. lactis and L. innocua at a minimal inhibitory concentration (MIC) of 6 g/ml and moderate to weak activities against B. cereus, S. epidermidis, S. uberis, and M. luteus (50-100 g/ml) (Boland and Separovic, 2006). The reference also reports the NMR structure in 70% TFE. The 3D structure of aurein 1.2 was also determined in SDS micelles and D8PG (Wang G et al. 2005 J Biol Chem 280: 5803-5811; Go to PDB). You can rotate, zoom, and view the 3D structure bound to micelles here in the PDB. In addition, aurein 1.2 F13W is HIV-1 inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). Found in multiple species. Updated 2/2014; 8/2015.

 
       
 

Title:

The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

 
 

Author:

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000

 
 

Reference:

Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.

 
       

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