Detailed Information About Peptide AP00013

APD ID:

AP00013

Name:

Aurein 1.2 (XXA, frog, amphibians, animals; BBMm; ZZH)

Source:

Southern bell frog

Sequence:

GLFDIIKKIAESF

Length:

13

Structure:

Helix

Method:

NMR

Additional info:

The reference also reports the NMR structure in TFE. For 3D structure determined in SDS micelles, see Wang et al. (2005) J Biol Chem 280: 5803-5811 (PDB ID: 1vm5). Aurein 1.2 F13W is HIV active (Wang G et al. 2009 submitted).

Crucial residues:

F13 and C-terminal amidation

Activity:

Gram+ & Gram-, Virus, Fungi, Cancer cells

Net charge:

0

Hydrophobic residue%:

53%

Boman Index:

0.12 kcal/mol

SwissProt ID:

PDB ID: 1VM5   Go to PDB

Reference:

Eur. J. Biochem. 267:5330-5341(2000)

Author:

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.

Title:

The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.