Antimicrobial Peptide AP00012

     
 

APD ID:

AP00012

 
 

Name/Class:

Aurein 1.1 (XXA, UCLL1c; frog, amphibians, animals)

 
 

Source:

Green and Golden Bell Frog, Litoria aurea and Litoria raniformis, Australia

 
 

Sequence:

GLFDIIKKIAESI

 
 

Length:

13

 
 

Net charge:

1

 
 

Hydrophobic residue%:

53%

 
 

Boman Index:

-0.02 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P82386  Go to SwissProt

 
 

Activity:

anti-Gram+, antifungal, Cancer cells

 
 

Additional info:

Active against B. cereus (MIC 50 ug/ml) and L. lactis (MIC 25 ug/ml) (provided by Chunfeng Wang). Shows anticancer activity if change last residue from I to F. Updated 9/2017.

 
       
 

Title:

The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

 
 

Author:

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000

 
 

Reference:

Eur J Biochem. 2000 Sep;267(17):5330-41. PubMed.

 
       

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