| |
APD ID: |
AP00010 |
|
| |
Name: |
BACTENECIN 7 (bac-7, bac 7; bac7; Pro-rich; cow cathelicidin, BBL, SeqAR, animals; BBPP) |
|
| |
Source: |
Bovine neutrophils Bos taurus |
|
| |
Sequence: |
RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL |
|
| |
Length: |
59 |
|
| |
Structure: |
Rich |
|
| |
Additional info: |
Rich in P and R. Bac7(1-35) has antibacterial activity similar to bac7. Mechanism of action: At ~MIC, the fragment binds to internal targets via stereospecific uptake (because all-D-enantiomer failed to be taken in and much less active); at higher concentrations, it works via non-specific membranolytic mechanism. Bac(1-16) is still active against E. coli and S. enterica but kinetically deficient compared to bac(1-35). Bac(5-35) is much less active, indicating the importance of the N-terminal segment (Biochim Biophys Acta 2006; 1760: 1732-1740). Updated 10/15/2008. |
|
| |
Crucial residues: |
N-terminal residues RRIR |
|
| |
Activity: |
Gram-, |
|
| |
Net charge: |
17 |
|
| |
Hydrophobic residue%: |
20% |
|
| |
Boman Index: |
3.29 kcal/mol |
|
| |
|
|
|
| |
SwissProt ID: |
SwissProt ID:
P19661 Go to SwissProt |
|
| |
Reference: |
Eur. J. Biochem. 1996; 238:769-776 |
|
| |
Author: |
Storici P., Tossi A., Lenarcic B., Romeo D. |
|
| |
Title: |
Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides. |
|
| |
|
|
|