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APD ID: |
AP00008 |
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Name: |
Bactenecin (Cyclic dodecapeptide, cow cathelicidin, animals, BBMm; JJsn) |
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Source: |
Bovine neutrophils |
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Sequence: |
RLCRIVVIRVCR |
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Length: |
12 |
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Structure: |
Bridge |
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Additional info: |
A S-S bond led to a CYCLIC DODECAPEPTIDE, which is more active against gram- bacteria. Only linearized versions of the peptides showed activtiy against Gram+ bacteria such as S. epidermidis and E. facaelis. The linearized or reduced forms appeared to be more effective in dissipating the membrane potential (Wu M and Hancock,RE 1999 JBC 274: 29-35). This peptide displayed synergistic effects with indolicidin (entry 150) against E. coli (Yan H & Hancock REW 2001 Antimicrob Agents Chemother 45: 1558-60). |
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Crucial residues: |
The S-S bond, charged Arg and amidation |
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Activity: |
Gram+ & Gram-, |
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Net charge: |
4 |
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Hydrophobic residue%: |
66% |
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Boman Index: |
2.52 kcal/mol |
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SwissProt ID: |
SwissProt ID:
P22226 Go to SwissProt |
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Reference: |
J Biol Chem. 1988 Jul 15;263(20):9573-5 |
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Author: |
Romeo D, Skerlavaj B, Bolognesi M, Gennaro R. |
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Title: |
Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. |
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