Antimicrobial Peptide AP00007

     
 

APD ID:

AP00007

 
 

Name/Class:

Apidaecin IB (Pro-rich; insects, arthropods, invertebrates, animals; Derivatives: Api88; Api137; BBribo)

 
 

Source:

honeybee, Apis mellifera L.

 
 

Sequence:

GNNRPVYIPQPRPPHPRL

 
 

Length:

18

 
 

Net charge:

4

 
 

Hydrophobic residue%:

16%

 
 

Boman Index:

2.97 kcal/mol

 
 

3D Structure:

Rich

 
 

SwissProt ID:

SwissProt ID: P35581  Go to SwissProt

 
 

Activity:

anti-Gram-,

 
 

Additional info:

Rich in P. Weakly active against G+ bacteira B. negaterium (MIC 100 ug/ml), but mainly G- bacteria E. coli, S. typhimurium, E. salicis (MIC 0.1 ug/ml or less) (see AP1210 for ref). Api88 (sequence: gu-ONNRPVYIPRPRPPHPRL-NH2, gu=N,N,N',N'-tetramethylguanidino) is an optimized analogue of apidaecin 1b with improved antibacterial activities. Api137 has the same amino acid sequence as Api88 but without C-terminal amidation. MOA: Api88 and Api137 interact with the 50S subunit of the 70S ribosome of bacteria. It can block the release of release factors from ribosomes. APi137 is the first such inhibitor identifed to date (Florin T et al., 2017). Animal model:mouse: It displayed high efficacy in systemic E. coli and K. pneumoniae septicemia infection mouse models (Ostorhazi E et al., 2014). Updated 7/2014; 12/2015; Jan2016; 7/2017 GW.

 
       
 

Title:

Apidaecins: antibacterial peptides from honeybees.

 
 

Author:

Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.1989

 
 

Reference:

EMBO J. 1989 Aug;8(8):2387-91. PubMed.

 
       

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