Antimicrobial Peptide AP00001

     
 

APD ID:

AP00001

 
 

Name/Class:

Dermaseptin-B2 (XXA, DRS-B2, Dermaseptin B2, DRS B2, DS bII, ADENOREGULIN; UCLL1c; frog, amphibians, animals)

 
 

Source:

Giant leaf frog, Phyllomedusa bicolor, South America

 
 

Sequence:

GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV

 
 

Length:

33

 
 

Net charge:

4

 
 

Hydrophobic residue%:

54%

 
 

Boman Index:

0.23 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P31107  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antifungal, Cancer cells

 
 

Crucial residues:

 
 

Additional info:

A frog used for "hunting magic" by several groups of Panoan-speaking Indians in the borderline between Brazil and Peru is identified as Phyllomedusa bicolor. This natural peptide, isolated from that frog skin, may contain a D amino acid residue, since it is not identical in chromatographic properties to the synthetic peptide (Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-3). Synthetic adenoregulin enhanced the binding of agonists to several G-protein-coupled receptors in rat brain membranes. Active against M. canis IP 1194, T. rubrum IP 1400-82, A. simii IP 1063-74, A. caviae IP 67-16 P, E. coli IP 76-24, P. aeruginosa (MIC 3.1 uM), S. aureus ATCC 25923 (MIC 0.7 uM), N. brasiliensis IP 16-80, C. neoformans IP 960-67, C. neoformans IP 962-67, and C. albicans (MIC 10-60 ug/ml). A helix-hinge-helix structural motif (helix 1: 1-8; helix 2: 11-31) was found in complex with SDS2003 micelles. The N-terminal segment residues 1-11 is critical for antibacterial activity (Lequin O et al. 2003 Biochemistry 42: 10311-23). Of note is that the structure in TFE is quite different. APD Updated 10/2008; 5/2014; 7/2017 GW.

 
       
 

Title:

Isolation and structure of novel defensive peptides from frog skin.

 
 

Author:

Mor, A., Nicolas, P.1994

 
 

Reference:

Eur J Biochem 1994, 219 (1-2):145-54. PubMed.

 
       

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