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APD ID: |
AP00001 |
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Name: |
Dermaseptin B2 (XXA, Drs B2, Dermaseptin-B2, DRS-B2, ADENOREGULIN, frog, amphibians, animals) |
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Source: |
S. American frog, Phyllomedusa bicolor |
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Sequence: |
GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV |
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Length: |
33 |
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Structure: |
Helix |
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Method: |
NMR |
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Additional info: |
A frog used for "hunting magic" by several groups of Panoan-speaking Indians in the borderline between Brazil and Peru is identified as Phyllomedusa bicolor. This natural peptide, isolated from that frog skin, may contain a D amino acid residue, since it is not identical in chromatographic properties to the synthetic peptide (Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-3). Synthetic adenoregulin enhanced the binding of agonists to several G-protein-coupled receptors in rat brain membranes. A helix(1-8)-hinge-helix(11-31) structural motif was found in complex with SDS micelles. The N-terminal segment residues 1-11 is critical for antibacterial activity (Lequin O et al. 2003 Biochemistry 42: 10311-23). Of note is that the structure in TFE is quite different. Updated 10/2008. |
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Activity: |
Gram+ & Gram-, Fungi, |
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Net charge: |
3 |
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Hydrophobic residue%: |
54% |
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Boman Index: |
0.23 kcal/mol |
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SwissProt ID: |
SwissProt ID:
P31107 Go to SwissProt |
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Reference: |
Eur J Biochem 1994, 219 (1-2):145-54 |
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Author: |
Mor, A., Nicolas, P. |
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Title: |
Isolation and structure of novel defensive peptides from frog skin. |
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