The APD2 - Contact Info


		Contact Guangshun Wang, Ph.D. Department of Pathology & Microbiology University of Nebraska Medical Center Phone: 402-559-4176 Fax: 402-559-4077 gwang@unmc.edu

	PI's Selected Publications Wang, Z., Wang, G.* (2004) APD: the Antimicrobial Peptide Database. Nucleic Acids Res 32, D590-D592. This is the original database paper that describes the construction of and the findings from the APD. Wang, G., Keifer, P.A., Peterkofsky, A. (2004)* Short-chain diacyl phosphatidylglycerols: which one to choose for NMR structural determination of a membrane-associated peptide from Escherichia coli? Spectroscopy 18, 257-264. D8PG is established as a new bacterial membrane-mimetic model for structural studies of membrane-targeting AMPs by solution NMR. Abstract. Wang, G., et al. (2005)* Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a non-toxic bacterial membrane anchor. J. Biol Chem. 280, 5803-5811. PDB entries: 1VM2, 1VM3, 1VM4, and 1VM5. Abstract. Wang, G.* (2006) Structural biology of antimicrobial peptides by NMR spectroscopy. Current Organic Chemistry 10, 569-581. This invited review article summarizes solution and solid-state NMR methods useful for AMP SAR studies.Abstract. Li, X., et al. (2006) Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc 128, 5776-85. Abstract. Wang, G.* (2007) Tool developments for structure-function studies of host defense peptides. Protein Peptide Letters 14, 57-69. An invited review. Abstract. Wang, G.* (2007) Determination of solution structure and lipid micelle location of an engineered membrane peptide by using one NMR experiment and one sample. Biochim. Biophys. Acta 1768, 3271-3281. This paper provides atomic details for AMP-PG interactions (i.e. Phe-PG and Arg-PG interactions) by solution NMR. Abstract. Wang, G.* (2008) NMR of membrane-associated peptides and proteins. Current Protein Peptide Science 9, 50-69. An invited review. Abstract. Wang, G., Waston, K., Buckheit, R., Jr. (2008)* Anti-human immunodeficiency virus type 1 (HIV-1) activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrobal Agents Chemotherapy 52, 3438-3440. Abstract. Wang, G.* (2008) Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. J. Biol. Chem. 283, 32637-32643. Click here to view the high-resolution LL-37 structure determined by 1H,13C,15N-3D NMR (Protein Data Bank PDB ID: 2K6O). Abstract. Wang, G., Li, X., Wang, Z. (2009)* APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Published online Oct. 28, 2008 Abstract/PDF . An invited article. Epand, R.F., Wang, G., Berno, B, Epand, R.M. (2009) Lipid segregation explains the antimicrobial activity of fragments of the human cathelicidin LL-37. Antimicrob. Agents Chemother. 53, 3705-3714. Abstract. Wang, G.* (2010) Structure, dynamics and mapping of membrane-binding residues of micelle-bound antimicrobial peptides by natural abundance 13C NMR spectroscopy. Biochim. Biophys. Acta 1798, 114-121. Abstract. Wang, G., Waston, K., Peterkofsky, A., Buckheit, R., Jr. (2010)* Identification of novel human immunodeficiency virus type 1 inhibitory peptides based on the antimicrobial peptide database. Antimicrob. Agents Chemother. 54, 1343-1346. Abstract. Epand, R.M., Epand, R.F., Arnusch, C., Papahadjopoulos-Sternberg, B., Wang, G., Shai, Y. (2010) Lipid clustering by three homologous arginine-rich antimicrobial peptides is insensitive to amino acid arrangement and induced secondary structure. Biochim. Biophys. Acta 1798, 1272-1280. Wang, G, Li, X., Zasloff, M. (2010) A database view of naturally occurring antimicrobial peptides: nomenclature, classification and amino acid sequence analysis. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic strategies". CABI, Oxfordshire, UK, pp. 1-21. Read the chapter here. Wang, G (2010) Database-aided prediction and design of novel antimicrobial peptides. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic strategies". CABI, Oxfordshire, UK, pp. 72-86. Wang, G* (2010) Structural studies of antimicrobial peptides provide insight into their mechanisms of action. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic strategies". CABI, Oxfordshire, UK, pp. 141-168. Wu, W.K.K., Wang, G., Coffelt, S.B., Betancourt, A.M., Lee, C.W., Yu, J., Sung, J.J.Y., Cho, C.H. (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. International Journal of Cancer 127(8), 1741-1747. Abstract. Wang, G., Epand, R.F., Mishra, B., Lushnikova, T., Thomas, V.C., Bayles, K.W., Epand, R. (2012)* Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37. Antimicrob. Agents Chemother. 56, 845-856. Published online Nov. 14, 2011. Abstract. Wang, G* (2012) Post-translational Modifications of Natural Antimicrobial Peptides and Strategies for Peptide Engineering. Current Biotechnology 1 72-79.Abstract. Wang, G., Elliott, M., Cogen, A.L., Ezell, E.L., Gallo, R.L., Hancock, R.E.W. (2012)* Structure, dynamics, antimicrobial and immune modulatory activities of human LL-23 and its single residue variants mutated based on homologous primate cathelicidins. Biochemistry 51, 653-664. Published online Dec. 20, 2011Abstract. * Corresponding author.

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